The pattern of symptoms in Cushing's syndrome can be highly unpredictable. The symptoms can vary from being very mild to very severe.
The pattern of symptoms in Cushing's syndrome can be highly unpredictable.
In some cases, the symptoms can develop quickly and be very severe. In other cases, the symptoms can develop gradually and be much milder.
Weight gain and fat deposits
Weight gain is the most common symptom of Cushing's syndrome, particularly on the chest, stomach and face. It occurs because cortisol causes fat to be redistributed to these areas.
People with Cushing's syndrome tend to have:
- slim arms and legs compared with their chest and stomach
- fat deposits on the back of the neck and shoulders – this is known as a "buffalo hump"
- a red, puffy, rounded face
Children who develop Cushing's syndrome tend to be obese and have slow growth rates.
Symptoms that affect the skin include:
- thin skin that bruises easily – cortisol causes proteins in the skin to break down and tiny blood vessels to become weak
- reddish-purple stretch marks on the thighs, stomach, buttocks, arms, legs or breasts – cortisol makes the skin fragile
- spots on the face, chest or shoulders
- darkened skin on the neck
- swollen ankles caused by a build-up of fluid (oedema)
- excessive sweating (hyperhidrosis)
- bruises, cuts, scratches and insect bites can take a long time to heal
Bones and muscles
People with Cushing's syndrome often have muscle weakness in their hips, shoulders, arms and legs.
Too much cortisol can also cause the bones to become weakened or brittle (osteoporosis). This may lead to problems, including:
- bone pain
- a bone fracturing during normal activities, such as bending and lifting
- loss of height
- a curved spine (kyphosis)
Depression and mood
Depression is common in people with Cushing's syndrome. It's also common to feel unusually tired all the time, which can contribute to feelings of depression.
People with Cushing's syndrome may also experience rapid mood swings or have emotional reactions that may seem inappropriate, such as laughing or crying for no apparent reason.
Other symptoms of Cushing's syndrome include: